The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial

Inclusion Criteria: * 18 years of age or older * Angiographically-confirmed multi-vessel coronary artery disease lesions with \>=70% in at least 2 major epicardial vessels in 2 or more coronary artery territories (left anterior descending (LAD), circumflex (CX) and right coronary artery (RCA)) OR lesions \>=50% in the left main (LM) * Patients who, in the opinion of the investigator, are amenable for coronary surgery through either median sternotomy or minimally-invasive approach. * Patients who are willing and able to comply with all follow-up study visits. Exclusion Criteria: * \<18 years of age * concomitant cardiac procedure with CABG (e.g. valve repair or replacement) * Previous cardiac surgery, mediastinal irradiation, or significant trauma to the chest * Contra-indications for MICS CABG, including: severe pectus excavatum; severe pulmonary disease; hemodynamically significant left subclavian stenosis; morbid obesity; severe left ventricular (LV) dysfunction; no adequate PDA or marginal branch target; absence of femoral pulse bilaterally. * Contraindications for conventional CABG via sternotomy * Concomitant life-threatening disease likely to limit life expectancy to \<2 years * Emergency CABG with hemodynamic compromise * Inability to provide informed consent.