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Signs and symptoms that signal a stroke
During a stroke, every minute counts. Fast treatment can lessen brain damage. Do you know the signs and symptoms? ...
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Can BBL™ HERO really treat multiple signs of aging 4x faster?
From drugstore products to professional cosmetic services, there's no shortage of things that promise to reverse visible signs of aging. So, what makes laser treatments unique—specifically BroadBand Light™ with new HERO (high-energy rapid output) technology?BBL HERO packs a punch of benefitsDon't have time to spend hours with your skincare specialist? Good news: BBL HERO is now four times faster than the treatment's older technology, so you can e ...
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Top 3 Noninvasive Cosmetic Treatments for Men
When it comes to cosmetic treatments for men, there are also plenty of noninvasive options to choose from to help you look and feel your best. Check out our top three! ...
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Gundersen Moundview recognized for outstanding stroke care
Stroke patients arriving in the hospital’s emergency department received a diagnostic CT head scan within a median time of 2.5 minutes. ...
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ARID3A and ARID3B induce stem promoting pathways in ovarian cancer cells
Paige Dausinas
ARID3A and ARID3B are paralogs from the AT-Rich interactive Domain (ARID) family. ARID3A and ARID3B associate to regulate genes in B-cells and cancer. We were the first to demonstrate that ARID3B regulates stem cell genes and promotes the cancer stem cell phenotype. Importantly, different knockout phenotypes in mice and distinct patterns of expression in adult animals suggests that ARID3A and ARID3B may have unique functions. In addition, high levels of ARID3B but not ARID3A induce cell death....
Can Stemness and Chemoresistance Be Therapeutically Targeted via Signaling Pathways in Ovarian Cancer?
Lynn Roy
Ovarian cancer is the most lethal gynecological malignancy. Poor overall survival, particularly for patients with high grade serous (HGS) ovarian cancer, is often attributed to late stage at diagnosis and relapse following chemotherapy. HGS ovarian cancer is a heterogenous disease in that few genes are consistently mutated between patients. Additionally, HGS ovarian cancer is characterized by high genomic instability. For these reasons, personalized approaches may be necessary for effective...
Evidence of a Protein-Coding Gene Antisense to the U<sub>L</sub>5 Gene in Bovine Herpesvirus I
Victoria A Jefferson
Bovine herpesvirus type 1 (BoHV-1) is an important agricultural pathogen that infects cattle and other ruminants worldwide. Though it was first sequenced and annotated over twenty years ago, the Cooper strain, used in this study, was sequenced as recently as 2012 and is currently said to encode 72 unique proteins. However, tandem mass spectrometry has identified several peptides produced during active infection that align with the BoHV-1 genome in unannotated regions. One of these abundant...
Gemcitabine combination therapies induce apoptosis in uterine carcinosarcoma patient-derived organoids
Matías J Dahl
Uterine carcinosarcoma (UCS) is a rare but aggressive endometrial cancer. Survival outcomes for women diagnosed with UCS remain poor with lower survival than those of endometrioid or high-grade serous uterine cancers. The histopathological hallmark of carcinosarcoma is the presence of both sarcomatous and carcinomatous elements. The survival rates for UCS have not improved for over 40 years; therefore, there is a profound need to identify new treatments. To investigate novel chemotherapy...
IKKα-Mediated Noncanonical NF-κB Signaling Is Required To Support Murine Gammaherpesvirus 68 Latency <em>In Vivo</em>
Brandon Cieniewicz
Noncanonical NF-κB signaling is activated in B cells via the tumor necrosis factor (TNF) receptor superfamily members CD40, lymphotoxin β receptor (LTβR), and B-cell-activating factor receptor (BAFF-R). The noncanonical pathway is required at multiple stages of B cell maturation and differentiation, including the germinal center reaction. However, the role of this pathway in gammaherpesvirus latency is not well understood. Murine gammaherpesvirus 68 (MHV68) is a genetically tractable system used...