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Clinical Trials
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Clinical trials at Gundersen for cancer, blood disorders and specialty conditions offer hope and answers. You could be the reason we find a cure.
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Training Programs
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Are you considering a job in healthcare? Our free training and certification programs will open the door to a career you love. Whether you’re seeking direct patient care or a role behind-the-scenes, we offer diverse programs to match diverse interests. You'll receive paid on-the-job training for many of our programs, plus a career at Gundersen with room for growth. Start your journey today.
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Sterile Processing Technician Training Program
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Sterile processing technicians, also called central service technicians, play a critical role in patient care, safety and infection prevention in our hospitals and clinics. Now you can begin a meaningful career as a sterile processing technician at Gundersen and receive free training to become a sterile processing technician.
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Paramedic Training Program
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Advance your EMT credentials and grow into a certified paramedic through Gundersen's paid, no-cost training program.
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Always worried? How to calm anxiety and take control of your mental health
Anxiety is a common mental health condition that affects millions of people worldwide. It can manifest in several different ways, including excessive worry, fear and physical symptoms, like sweating and a rapid heartbeat. If left unmanaged, anxiety can significantly impact a person's daily life and overall well-being. However, there are many simple, helpful ways to get your anxiety under control and positively boost your mental health. Read on to ...
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The gift of life for a friend, coworker
Besides his family, it’d be hard to find anything Andy Pavlovec loved more than bicycling. He’s ridden for thousands of miles. But one particular ride in 2021 would turn out to be his last. ...
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Gundersen Renal Dialysis Center La Crosse
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Gundersen Lutheran Medical Center in La Crosse provides acute dialysis to hospital inpatients 24/7. Outpatients with acute renal failure may receive services at the La Crosse location. Consult your healthcare provider regarding home dialysis options.
ARID3A and ARID3B induce stem promoting pathways in ovarian cancer cells
Paige Dausinas
ARID3A and ARID3B are paralogs from the AT-Rich interactive Domain (ARID) family. ARID3A and ARID3B associate to regulate genes in B-cells and cancer. We were the first to demonstrate that ARID3B regulates stem cell genes and promotes the cancer stem cell phenotype. Importantly, different knockout phenotypes in mice and distinct patterns of expression in adult animals suggests that ARID3A and ARID3B may have unique functions. In addition, high levels of ARID3B but not ARID3A induce cell death....
Can Stemness and Chemoresistance Be Therapeutically Targeted via Signaling Pathways in Ovarian Cancer?
Lynn Roy
Ovarian cancer is the most lethal gynecological malignancy. Poor overall survival, particularly for patients with high grade serous (HGS) ovarian cancer, is often attributed to late stage at diagnosis and relapse following chemotherapy. HGS ovarian cancer is a heterogenous disease in that few genes are consistently mutated between patients. Additionally, HGS ovarian cancer is characterized by high genomic instability. For these reasons, personalized approaches may be necessary for effective...
Evidence of a Protein-Coding Gene Antisense to the U<sub>L</sub>5 Gene in Bovine Herpesvirus I
Victoria A Jefferson
Bovine herpesvirus type 1 (BoHV-1) is an important agricultural pathogen that infects cattle and other ruminants worldwide. Though it was first sequenced and annotated over twenty years ago, the Cooper strain, used in this study, was sequenced as recently as 2012 and is currently said to encode 72 unique proteins. However, tandem mass spectrometry has identified several peptides produced during active infection that align with the BoHV-1 genome in unannotated regions. One of these abundant...
Gemcitabine combination therapies induce apoptosis in uterine carcinosarcoma patient-derived organoids
Matías J Dahl
Uterine carcinosarcoma (UCS) is a rare but aggressive endometrial cancer. Survival outcomes for women diagnosed with UCS remain poor with lower survival than those of endometrioid or high-grade serous uterine cancers. The histopathological hallmark of carcinosarcoma is the presence of both sarcomatous and carcinomatous elements. The survival rates for UCS have not improved for over 40 years; therefore, there is a profound need to identify new treatments. To investigate novel chemotherapy...
IKKα-Mediated Noncanonical NF-κB Signaling Is Required To Support Murine Gammaherpesvirus 68 Latency <em>In Vivo</em>
Brandon Cieniewicz
Noncanonical NF-κB signaling is activated in B cells via the tumor necrosis factor (TNF) receptor superfamily members CD40, lymphotoxin β receptor (LTβR), and B-cell-activating factor receptor (BAFF-R). The noncanonical pathway is required at multiple stages of B cell maturation and differentiation, including the germinal center reaction. However, the role of this pathway in gammaherpesvirus latency is not well understood. Murine gammaherpesvirus 68 (MHV68) is a genetically tractable system used...
Lytic Replication and Reactivation from B Cells Is Not Required for Establishing or Maintaining Gammaherpesvirus Latency <em>In Vivo</em>
Arundhati Gupta
Gammaherpesviruses (GHVs) are lymphotropic tumor viruses with a biphasic infectious cycle. Lytic replication at the primary site of infection is necessary for GHVs to spread throughout the host and establish latency in distal sites. Dissemination is mediated by infected B cells that traffic hematogenously from draining lymph nodes to peripheral lymphoid organs, such as the spleen. B cells serve as the major reservoir for viral latency, and it is hypothesized that periodic reactivation from...
MAPK Signaling Is Required for Generation of Tunneling Nanotube-Like Structures in Ovarian Cancer Cells
Jennifer M Cole
Ovarian cancer (OC) cells survive in the peritoneal cavity in a complex microenvironment composed of diverse cell types. The interaction between tumor cells and non-malignant cells is crucial to the success of the metastatic process. Macrophages activate pro-metastatic signaling pathways in ovarian cancer cells (OCCs), induce tumor angiogenesis, and orchestrate a tumor suppressive immune response by releasing anti-inflammatory cytokines. Understanding the interaction between immune cells and...
The miR-23a∼27a∼24-2 microRNA Cluster Promotes Inflammatory Polarization of Macrophages
Austin Boucher
Macrophages are critical for regulating inflammatory responses. Environmental signals polarize macrophages to either a proinflammatory (M1) state or an anti-inflammatory (M2) state. We observed that the microRNA (miRNA) cluster mirn23a, coding for miRs-23a, -27a, and -24-2, regulates mouse macrophage polarization. Gene expression analysis of mirn23a-deficient myeloid progenitors revealed a decrease in TLR and IFN signaling. Mirn23a ^(-/-) bone marrow-derived macrophages (BMDMs) have an...
Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues
Kyle R Smith
Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair. Mammalian uracil-DNA glycosylases (UNG) excise deleterious uracil residues from their genomic DNA. Each herpesvirus UNG studied to date has demonstrated conservation of the enzymatic function to excise uracil residues from DNA. We previously reported that a murine gammaherpesvirus (MHV68) with a stop codon in ORF46 (ORF46.stop) that...