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Emergence and onward transmission of a SARS-CoV-2 E484K variant among household contacts of a bamlanivimab-treated patient

Arick P Sabin
The implementation of monoclonal antibody therapeutics during the COVID-19 pandemic altered the selective pressures encountered by SARS-CoV-2, raising the possibility of selection for resistant variants. Within-host viral evolution was reported in treated immunocompromised individuals but whether this signifies a real risk of onward transmission is unclear. We used a regional SARS-CoV-2 sequencing program to monitor lineages with clinically relevant variants in identified patients, which...

Emergence and onward transmission of a SARS-CoV-2 E484K variant among household contacts of a bamlanivimab-treated patient

Arick P Sabin
The implementation of monoclonal antibody therapeutics during the COVID-19 pandemic altered the selective pressures encountered by SARS-CoV-2, raising the possibility of selection for resistant variants. Within-host viral evolution was reported in treated immunocompromised individuals but whether this signifies a real risk of onward transmission is unclear. We used a regional SARS-CoV-2 sequencing program to monitor lineages with clinically relevant variants in identified patients, which...

Optimized infection control practices augment the robust protective effect of vaccination for ESRD patients during a hemodialysis facility SARS-CoV-2 outbreak

Megan E Meller
CONCLUSIONS: Prompt recognition of an infection cluster and rapid intervention efforts successfully ended the outbreak. Alongside consistent adherence to core infection prevention measures, vaccination was highly effective in reducing disease incidence and morbidity in this vulnerable population.

Optimized infection control practices augment the robust protective effect of vaccination for ESRD patients during a hemodialysis facility SARS-CoV-2 outbreak

Megan E Meller
CONCLUSIONS: Prompt recognition of an infection cluster and rapid intervention efforts successfully ended the outbreak. Alongside consistent adherence to core infection prevention measures, vaccination was highly effective in reducing disease incidence and morbidity in this vulnerable population.

Outbreak or pseudo-outbreak? Integrating SARS-CoV-2 sequencing to validate infection control practices in a dialysis facility

Bridget L Pfaff
CONCLUSIONS: With high community prevalence, epidemiological data alone is insufficient to deem a case cluster an outbreak. Cluster evaluation with genomic data, when available with a short turn-around time, can play an important role in infection prevention and control response programs.

Pan-cancer distribution of cleaved cell-surface amphiregulin, the target of the GMF-1A3 antibody drug conjugate

Kristopher A Lofgren
Amphiregulin is a transmembrane protein which, when cleaved by the TACE/ADAM17 protease, releases a soluble epidermal growth factor receptor ligand domain that promotes proliferation of normal and malignant cells. We previously described a rabbit monoclonal antibody, GMF-1A3, that selectively recognizes the cell-associated cleaved amphiregulin epitope. Antibody-drug conjugates had anti-tumor activity against human breast cancer xenografts. Several tumor types express amphiregulin, but evidence...
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Family Medicine Obstetrics (OB) Fellowship
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We offer surgical obstetrics training to a new resident or a Family Medicine physician practicing inside or outside Gundersen. We’re proud to be the first organization in Wisconsin that did.
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Family Medicine OB Application
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We offer surgical obstetrics training to a Family Medicine physician who has just completed their residency or who is already in practice. Apply between Jan. 1 and Aug. 1, 2024. Fellowship starts on July 1, 2025.
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Body Cosmetic Services
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Most people are happiest when they feel at home in their body. Sometimes that means giving yours a little extra cosmetic care. Whether it’s getting rid of stubborn fat bulges with advanced treatments like CoolSculpting®, minimizing varicose veins, having moles removed, or trying other cosmetic services, we can help you love what’s on the outside as much as what's on the inside.
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Skin Cosmetic Services
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At first blush you may not think Gundersen when you think about chemical peels, laser treatments and other skin rejuvenating services. But there’s a reason our Cosmetic Services clients keep coming back. We help you achieve healthier, younger-looking skin while prioritizing safety and privacy. This means you can rest easy knowing your beauty goals are in the hands of experts.
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Permanent Makeup
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Ever wished you could spend less time in front of your mirror? Or that you could enjoy a flawless face without retouching your makeup too often? You can. Permanent makeup simplifies morning routines while enhancing your natural beauty all day (and night) long.
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Injectable Fillers and BOTOX®
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You’ve heard of them...crow’s feet, bunny lines, tear troughs. The list goes on. If facial lines have become a distraction when you look in the mirror—or you desire plumper lips or more contoured cheeks—we can help you love your reflection again. Add volume, smooth and contour with injectables, dermal fillers and BOTOX®.
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Nursing Careers
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Looking for a nursing career to love? You'll find fulfillment as you practice highly specialized care, delivered with a personal touch at Gundersen. We call it love + medicine.
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Gundersen Boscobel Area Hospital
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Our critical access hospital serves our neighbors in Boscobel, Fennimore, Muscoda and surrounding communities with the primary, emergency and specialty care they need. You can help us better understand the health concerns and needs of our communities by taking the 2024 Community Health Needs Assessment survey.

1900 South Ave.
La Crosse, WI 54601

(608) 782-7300
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