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news
New year, new name and locations for Gundersen regional ambulance service

 
 New year, new name and locations for Gundersen regional ambulance service Patients and communities served by Gundersen Health System will soon experience improved ambulance service and see a new name and look on vehicles. Gundersen Tri-State Regional Ambulance is now Gundersen Health System Ambulance. In addition to its current locations in West Union, Iowa and Prairi ...
news
Critical Care nurse: COVID-19 is straining us, and it’s preventable

 
 Critical Care nurse: COVID-19 is straining us, and it’s preventable Critical Care nurses and staff are exhausted. What if the next person who needs us is your mother? Your child? You? We’re almost two years into a deadly global pandemic. Patients battling COVID-19 fill Gundersen’s Critical Care Unit in La Crosse, where I work as a nurse for 12-h ...
news
Kurt Wilhelm, MD, retires after tenure of medical service to Boscobel
  Kurt Wilhelm, MDDec. 30, 2021, marked the end of an era at Gundersen Boscobel Area Hospital and Clinics with the retirement of Kurt Wilhelm, MD.  A familiar name in Boscobel and surrounding communities, Dr. Wilhelm practiced Family Medicine at the Boscobel Clinic and provided emergency care at the Boscobel hospital. He also served as medical director for several local emergency service units and medi ...
news
La Crosse ExpressCare offers COVID vaccine

 
 COVID-19 vaccine for eligible groups will be offered at the La Crosse ExpressCare Clinic in the Village Shopping Center starting Jan. 24 for scheduled appointments only.  La Crosse ExpressCare hours are 8 a.m. to 6:30 p.m. Monday through Friday, 8 a.m. to 4:30 p.m. Saturday, and 9 a.m. to 3:30 p.m. Sunday. Vaccine appointments at La Crosse ExpressCare can be scheduled b ...
news
Gundersen Home Hospital expands to more patients

 
 Program brings hospital-level care into patients’ homes, decreasing unnecessary hospital stays and improving patient outcomes When Cliff Johnson had trouble breathing, his wife took him to Gundersen Health System’s Hospital in La Crosse. The nearly 80-year-old lives with claustrophobia and feared nights alone in a hospital room. That’s when he was approached about Gunder ...
news
How a little-known heart attack changed this mom’s life
    Brenda Creighton had just gotten home from work on a Friday evening in 2018 when she felt an immediate tightness and tension in her chest. The 45-year-old mother of two had no history of cardiac issues and had recently visited her primary care provider, ensuring she was in great health. The pain in her chest continued and traveled down her left arm. And then the base of her neck and skull began to ache. Creighton took an a ...
news
During American Hearth Month, take steps to protect your heart
  Colleen McCurry, MDAbout 90 percent of women have risk factors for heart disease, yet many of them are unaware that it is the greatest threat to their health.“Women's symptoms of heart disease can be subtle compared to men's, and their response to them is often delayed,” said Colleen McCurry, MD, Family Medicine, Gundersen Boscobel. “Women may feel tired or easily fatigued, but they often make excuses to themselves about what is happe ...
news
Area organizations partner to assess community health needs
  Area organizations are working together in partnership to help improve the health of their communities, and the region. Partnering organizations include:  Gundersen Boscobel Area Hospital and Clinics, Grant Regional Health Center, Crossing Rivers Health, Grant and Crawford County UW Extension, Aging and Disability Resource Centers, and Grant and Crawford County Health Departments. The group conducted a community health needs ass ...
news
New Gundersen HR VP leads with people-first focus

 
 New Gundersen HR VP leads with people-first focus Shannon Mulligan will tell you success can often be found in the three “P’s.” “People. Purpose. Possibility. Connecting these incredibly important elements is key to creating the experiences we want for everyone the organization serves – employees, consumers, and the community. With a focus on people and alignment to a c ...
news
Cardiac Rehab offers a second chance on life — and love
  Cardiac Rehab offers a second chance on life — and love At 9 a.m. every Monday, Wednesday and Friday morning, a group of 12 shows up to Cardiac Rehab at Gundersen St. Elizabeth’s ready to sweat. And chat. And maybe just fall in love. At least that’s what happened for Connie Reeser and Mike Brown. They’ve been given a second chance at life – and love. In 2019, Reeser was diagnosed with Non-Hodgkin Lymphoma; consistent exercise help ...
news
Together for life until separated by COVID-19, care staff rejoin couple in his final days
  His body failed to respond to treatment for COVID-19. Hospitalized in Gundersen’s unit for patients infected with the virus, now was the time for comfort measures and compassionate care.Hope Sternberg, RN, almost didn’t believe he had reached the end of his life.“He had so much energy and was so talkative,” she said. “I asked if he wanted ice cream and he said, ‘Only one scoop because I don’t want to get fat.’”He’d changed the next da ...

ARID3A and ARID3B induce stem promoting pathways in ovarian cancer cells

Paige Dausinas
ARID3A and ARID3B are paralogs from the AT-Rich interactive Domain (ARID) family. ARID3A and ARID3B associate to regulate genes in B-cells and cancer. We were the first to demonstrate that ARID3B regulates stem cell genes and promotes the cancer stem cell phenotype. Importantly, different knockout phenotypes in mice and distinct patterns of expression in adult animals suggests that ARID3A and ARID3B may have unique functions. In addition, high levels of ARID3B but not ARID3A induce cell death....

Can Stemness and Chemoresistance Be Therapeutically Targeted via Signaling Pathways in Ovarian Cancer?

Lynn Roy
Ovarian cancer is the most lethal gynecological malignancy. Poor overall survival, particularly for patients with high grade serous (HGS) ovarian cancer, is often attributed to late stage at diagnosis and relapse following chemotherapy. HGS ovarian cancer is a heterogenous disease in that few genes are consistently mutated between patients. Additionally, HGS ovarian cancer is characterized by high genomic instability. For these reasons, personalized approaches may be necessary for effective...

Evidence of a Protein-Coding Gene Antisense to the U<sub>L</sub>5 Gene in Bovine Herpesvirus I

Victoria A Jefferson
Bovine herpesvirus type 1 (BoHV-1) is an important agricultural pathogen that infects cattle and other ruminants worldwide. Though it was first sequenced and annotated over twenty years ago, the Cooper strain, used in this study, was sequenced as recently as 2012 and is currently said to encode 72 unique proteins. However, tandem mass spectrometry has identified several peptides produced during active infection that align with the BoHV-1 genome in unannotated regions. One of these abundant...

Gemcitabine combination therapies induce apoptosis in uterine carcinosarcoma patient-derived organoids

Matías J Dahl
Uterine carcinosarcoma (UCS) is a rare but aggressive endometrial cancer. Survival outcomes for women diagnosed with UCS remain poor with lower survival than those of endometrioid or high-grade serous uterine cancers. The histopathological hallmark of carcinosarcoma is the presence of both sarcomatous and carcinomatous elements. The survival rates for UCS have not improved for over 40 years; therefore, there is a profound need to identify new treatments. To investigate novel chemotherapy...

IKKα-Mediated Noncanonical NF-κB Signaling Is Required To Support Murine Gammaherpesvirus 68 Latency <em>In Vivo</em>

Brandon Cieniewicz
Noncanonical NF-κB signaling is activated in B cells via the tumor necrosis factor (TNF) receptor superfamily members CD40, lymphotoxin β receptor (LTβR), and B-cell-activating factor receptor (BAFF-R). The noncanonical pathway is required at multiple stages of B cell maturation and differentiation, including the germinal center reaction. However, the role of this pathway in gammaherpesvirus latency is not well understood. Murine gammaherpesvirus 68 (MHV68) is a genetically tractable system used...

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