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Detection of antibodies to decorin-binding protein A (DbpA) and DbpB after infection of dogs with <em>Borrelia burgdorferi</em> by tick challenge

Darby G Oldenburg
We characterized the antibody response to decorin-binding protein A (DbpA) or DbpB from immune serum samples collected from 27 dogs infected with Borrelia burgdorferi by Ixodes scapularis ticks. Immunoglobulin M (IgM) antibodies to DbpA or DbpB were rarely detected, but high levels of IgG antibodies to DbpA were detected in 16 of 27 of the immune sera collected 1 mo after infection, 20 of 25 of the sera collected after 2 mo, and each of the 23, 17, or 11 serum samples evaluated after 3, 4, or 5...

Emergence and onward transmission of a SARS-CoV-2 E484K variant among household contacts of a bamlanivimab-treated patient

Arick P Sabin
The implementation of monoclonal antibody therapeutics during the COVID-19 pandemic altered the selective pressures encountered by SARS-CoV-2, raising the possibility of selection for resistant variants. Within-host viral evolution was reported in treated immunocompromised individuals but whether this signifies a real risk of onward transmission is unclear. We used a regional SARS-CoV-2 sequencing program to monitor lineages with clinically relevant variants in identified patients, which...

Emergence and onward transmission of a SARS-CoV-2 E484K variant among household contacts of a bamlanivimab-treated patient

Arick P Sabin
The implementation of monoclonal antibody therapeutics during the COVID-19 pandemic altered the selective pressures encountered by SARS-CoV-2, raising the possibility of selection for resistant variants. Within-host viral evolution was reported in treated immunocompromised individuals but whether this signifies a real risk of onward transmission is unclear. We used a regional SARS-CoV-2 sequencing program to monitor lineages with clinically relevant variants in identified patients, which...

Optimized infection control practices augment the robust protective effect of vaccination for ESRD patients during a hemodialysis facility SARS-CoV-2 outbreak

Megan E Meller
CONCLUSIONS: Prompt recognition of an infection cluster and rapid intervention efforts successfully ended the outbreak. Alongside consistent adherence to core infection prevention measures, vaccination was highly effective in reducing disease incidence and morbidity in this vulnerable population.

Optimized infection control practices augment the robust protective effect of vaccination for ESRD patients during a hemodialysis facility SARS-CoV-2 outbreak

Megan E Meller
CONCLUSIONS: Prompt recognition of an infection cluster and rapid intervention efforts successfully ended the outbreak. Alongside consistent adherence to core infection prevention measures, vaccination was highly effective in reducing disease incidence and morbidity in this vulnerable population.

Outbreak or pseudo-outbreak? Integrating SARS-CoV-2 sequencing to validate infection control practices in a dialysis facility

Bridget L Pfaff
CONCLUSIONS: With high community prevalence, epidemiological data alone is insufficient to deem a case cluster an outbreak. Cluster evaluation with genomic data, when available with a short turn-around time, can play an important role in infection prevention and control response programs.

Pan-cancer distribution of cleaved cell-surface amphiregulin, the target of the GMF-1A3 antibody drug conjugate

Kristopher A Lofgren
Amphiregulin is a transmembrane protein which, when cleaved by the TACE/ADAM17 protease, releases a soluble epidermal growth factor receptor ligand domain that promotes proliferation of normal and malignant cells. We previously described a rabbit monoclonal antibody, GMF-1A3, that selectively recognizes the cell-associated cleaved amphiregulin epitope. Antibody-drug conjugates had anti-tumor activity against human breast cancer xenografts. Several tumor types express amphiregulin, but evidence...
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Family Medicine Residency
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We’re proud to offer an innovative, full-spectrum residency program that provides outstanding training with a unique rural focus. You’ll graduate after three years together prepared to deliver comprehensive care to patients of all ages.
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Aging Well
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Your health and wellness is important at every age. Read these articles and discover ways to feel your best at every step of your life.
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Gundersen Dental Specialties Prairie du Chien
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Our Gundersen Oral & Maxillofacial Surgery and Orthodontic teams provide care close to home at the Gundersen Dental and Eye Clinic in Prairie du Chien. From tooth extraction and dental implants to braces and Invisalign®, we offer many treatment options to meet your needs. Call for a free consultation.
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Gundersen Dental Specialties Tomah
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Our Gundersen Orthodontic and Oral & Maxillofacial Surgery teams provide care close to home at the Gundersen Tomah Clinic. From tooth extraction and dental implants to braces and Invisalign®, we offer a range of treatment options to meet your needs. Call for a free consultation.
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How to raise an intuitive eater
&nbsp;Back to school preparations are underway! While you're checking off items on school supplies lists and shopping for clothes for those growing bodies, you may also be thinking about getting back to packing lunches or talking with your child about the school lunch menu. But for the time being, let's put aside the idea of what your child is eating and consider how they are eating.Kids are born intuitive eaters; they are self-regulating in term ...
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3 reasons you've quit exercising
&nbsp;We're a couple months into the New Year; how are those lifestyle changes coming along? If exercise is one of your New Year's resolutions but you're struggling to keep it up, you're not alone! Here's some advice on how to overcome three major obstacles:You're not losing weight. This is one of the biggest reasons we struggle to keep up exercising habits. We work so hard, hitting the gym religiously for months, and after "only losing five poun ...
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Is coconut oil really that beneficial?
&nbsp;The reputation that coconut oil has as a healing power is not new; from improving skin and hair care to boosting immunity and even weight loss, the health claims of this tropical oil are endless. But the question remains: should you switch to using coconut oil in your diet? Here's a breakdown of the pros and cons.The prosIts tropical taste lends a distinctive flavor to dishes that differs from other fats or oils.It's solid at room temperatu ...

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