Multidisciplinary Research

• The Chronicle Study: A Longitudinal Prospective Observational Study of the Characteristics, Treatment Patterns and Health Outcomes of Individuals with Severe Asthma in the United States.

• The MIST Trial: Minimally Invasive Coronary Surgery Compared to Sternotomy Coronary Artery Bypass Grafting

• No studies available at this time.

• No studies available at this time.

• The C-TRACT Trial: Chronic venous thrombosis: relief with adjunctive catheter-directed therapy
• BEST Trial: Best Endovascular vs Best Surgical Therapy in Patients With Critical Limb Ischemia
• TIDE (Best ancillary study): The Impact of Diabetes on REvascularization in BEST-CLI (TIDE)
• BEST Registry: Prospective multicenter registry evaluating the real world therapeutic strategies, clinical outcomes, and costs associated with patients presenting with critical limb ischemia.

• No studies available at this time.

• Crest-2: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (Crest-2) Protocol
• CREST-H: Carotid Revascularization and Medical Management for Asymptomatic Carotid stenosis - Hemodynamics
• INSYTE: Management of Parkinson’s Disease
  Psychosis in Actual Practice

• Children’s Health in the Heartland Study (CHHS): This study will measure biological and epigenetic biomarkers from mother-baby pairs to assess the extent of prenatal GBH (glyphosphate-based herbicide) pesticide exposures in pregnant Midwestern women and associations with adverse reproductive outcomes and the developing child. Additionally, epigenetic biomarkers may also be measured to further assess paternal exposure effects.

• IXT5: Intermittent Exotropia Study 5: A Randomized Clinical Trial of Overminus 9 Spectacle Therapy for Intermittent Exotropia

• Active Spacer: A Prospective Post-market Study to determine the effect of the Active Spacer on soft tissue balancing and patient reported outcomes measures (PROMs) in robotic-assisted total knee arthroplasty.

• No studies available at this time.

• 133-CL-01: Vectra Involved Informed Decision Outcome Study (VIVID): A prospective randomized controlled trial evaluating the effect of guided care with Vectra compared to treatment as usual in patients with rheumatoid arthritis

• Zenith: Low profile AAA Endovascular Graft Clinical Study

Clinical research at Gundersen vital to FDA approval process

For several years, Gundersen Health System has joined with other major medical centers to conduct research trials essential in determining the safety and effectiveness of new medicines and technologies. Many Gundersen departments have participated in these trials—among them Cardiology, Endocrinology, Family Practice, Internal Medicine, Neurology, Pediatrics, Pulmonary, Rheumatology and Urology.

The Clinical Research department is self-supporting. All or most clinical trial-related costs such as clinic visits, laboratory tests, study drugs or devices and patient stipends for time and travel expenses are paid for with funds provided by the sponsoring pharmaceutical or medical device companies.

All patient participation in clinical trials is voluntary. Some patients volunteer hoping to benefit from a promising new medication or treatment that is not yet approved by the Food and Drug Administration. Most patients also are motivated by a desire to help others by providing information that could increase understanding and lead to better treatments.