Non-Cancer Clinical Trials
The multi-specialty research group supports research in:
- Liberty: a randomized, double blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of dupilumab in children 6-12 years of age with uncontrolled asthma. Protocol number EFC14153
ANDHI: A Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled, Phase 3b Study to Evaluate the Safety and Efficacy of Benralizumab 30 mg sc in Patients with Severe Asthma Uncontrolled on Standard of Care Treatment. Protocol Number: D3250C00045
- HYBRID: Randomized Trial of Hybrid Coronary
Revascularization Versus Percutaneous Coronary Intervention
- BEST Trial: Best Endovascular vs Best Surgical Therapy in Patients With Critical Limb Ischemia
- Crest-2: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (Crest-2) Protocol
- INSYTE: Management of Parkinson’s Disease
Psychosis in Actual Practice
- SMART study: A Prospective, Multicenter Study Assessing the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil
- Markers of Preterm Birth study: Distinguishing an RNA expression pattern in blood that distinguishes women with preterm labor from women with full term labor.
- CHAP: Chronic Hypertension and Pregnancy
- Active Spacer: A Prospective Post-market Study to determine the effect of the Active Spacer on soft tissue balancing and patient reported outcomes measures (PROMs) in robotic-assisted total knee arthroplasty.
- AWARE: Comparative and Pragmatic Study of Golimumab Intravenous (IV) (Simponi Aria) Versus Infliximab (Remicade) in Rheumatoid Arthritis (AWARE). Closed to Enrollment.
- Axial Spondyloarthritis (AS0006): Phase 3, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Efficacy and Safety of Certilozumab Pegol in Subjects with Active Axial Spondyloarthritis (AxSpa) without X-Ray Evidence of Ankylosing Spondylitis (AS) and Objective Signs of Inflammation. Closed to Enrollment.
- Vectra- Prospective Outcomes Study: Vectra DA Guided Care Compared to Usual Care
- AbbVie M14-465: A Phase 3, Randomized, Double-Blind Study Comparing ABT-494 to Placebo and to Adalimumab in Subjects with Moderately to Severely Active Rheumatoid Arthritis Who are on Stable Background of Methotrexate (MTX) and Who Have an Inadequate Response to MTX (MTX-IR). Closed to Enrollment.
Industry Sponsored Research
Clinical research at Gundersen vital to FDA approval process
For several years, Gundersen Health System has joined with other major medical centers to conduct research trials essential in determining the safety and effectiveness of new medicines and technologies. Many Gundersen departments have participated in these trials—among them Cardiology, Endocrinology, Family Practice, Internal Medicine, Neurology, Pediatrics, Pulmonary, Rheumatology and Urology.
The Clinical Research department is self-supporting. All or most clinical trial-related costs such as clinic visits, laboratory tests, study drugs or devices and patient stipends for time and travel expenses are paid for with funds provided by the sponsoring pharmaceutical or medical device companies.
All patient participation in clinical trials is voluntary. Some patients volunteer hoping to benefit from a promising new medication or treatment that is not yet approved by the Food and Drug Administration. Most patients also are motivated by a desire to help others by providing information that could increase understanding and lead to better treatments.